Development of liquisolid systems containing tadalafil
Abstract
7 ABSTRACT Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: doc. PharmDr. Barbora Vraníková, Ph.D. Konzultant: M.Sc. Noemi Frigola Verhein Student: Eliška Straková Title of Thesis: Development of liquisolid systems containing tadalafil In current pharmaceutical research, the limited solubility of drugs represents a significant factor affecting their bioavailability after oral administration. One of the promising strategies to address this issue is the preparation of liquisolid systems. For this reason, the present study focused on the preparation of liquisolid systems containing the poorly water-soluble drug tadalafil. Polyethylene glycol 200 was used as a non-volatile solvent, either alone or in combination with surfactants (cetyltrimethylammonium bromide, sodium lauryl sulfate, polysorbate 20, or polysorbate 80), while the mesoporous magnesium aluminometasilicate Neusilin® US2 was utilized as the carrier. The results demonstrated that formulation of tadalafil into liquisolid systems led to faster drug release in all cases compared to pure tadalafil. However, increasing the proportion of tadalafil in the dispersion resulted in a slower release from the system. The findings also suggest that combining polyethylene glycol 200 with surfactants does...
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