The Effects of Tadalafil on the Liver After Intraperitoneal Injury in Rats
Abstract
Objective: Liver is one of the most affected tissues after abdominopelvic surgery.Many substances were employed to prevent liver damage during surgery.In this study, we aimed to investigate effects of tadalafil, phosphodiesterase-5 (PDE-5) inhibitor, on the liver after intraperitoneal abrasion. Materials and Methods:Thirty rats were induced ileal and cecal abrasion model.Subsequently, group 1: received saline (control), group 2: tadalafil 1 mg/kg, group 3: tadalafil 10 mg/kg, group 4: tadalafil 1 mg/kg for 7 days, group 5: tadalafil 10 mg/kg for 7 days.After treatments, serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) were analyzed by ELISA.Liver tissue samples were analyzed for tissue total oxidant/antioxidant status (TOS, TAS), thiol, TTL (total thiol level), NTL (native thiol level) using colorimetric appropriate methods. Results:We found that serum ICAM-1 in group 5 was higher than other groups, ICAM-1 in group 4 was higher than group 2 (g1 vs. g5 p<0.001, g2 vs. g4 p=0.016, g2 vs. g5 p<0.001, g3 vs. g5 p=0.004, g4 vs. g5 p=0.03).PDGF was higher in group 5 than group 1 (p=0.025).Tissue TTL and NTL were higher in group 5 than in group 1 (p=0.035,p=0.002).TOS was higher in group 5 than groups 1 and 4 (p=0.028,p=0.028).TAS was higher in group 5 than group 3 (p=0.018).Conclusion: High-dose and long-term administration of tadalafil increased oxidative and inflammatory responses in…
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