Biochemical role of Tadalafil in experimental brain impairment activities in mice
Abstract
Tadalafil (TAD) is an FDA-approved selective long-acting phosphodiesterase 5 inhibitor (PDE5-I) for the treatment of male erectile dysfunction (ED). It also helps to improve cognitive function by lowering neuroinflammation and amyloid beta deposition. A bi ological, pharmacological, or physical toxicity that impairs the function of the central and/or peripheral nerve systems is referred to as brain impairment. Aluminum poisoning may affect the brain;, causing aberrant amyloid-beta (Aß) buildup, neuroinflammation, and neuronal death. This study included sixty mice divided into three groups. (20 each), control group: Mice were given no medication. aluminum chloride group: Mice were received AlCl3daily at dose (8.5 mg/kg) for 4weeks .Tadalafil and ALCL₃ group: mice were received tadalafil (20 mg/kg/day) and ALCL₃ (8.5 mg/kg) for 4 weeks. Administration of ALCL₃ increases the level of brain Lactate, Pyruvate, acetylcholinesterase (AchE), Gamma-aminobutyric acid (GABA) and Brain Myeloperoxidase (MPO) activities. Whereas, tadalafil administration showing protective role as it causing significant decrease in all parameters. From the obtained results, it could be concluded that tadalafil has a neuroprotective effect against aluminum chloride induced brain impairment in mice.
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