Repurposed Tadalafil-Rapamycin Combination for Penile Tissue Engineering
Abstract
Tadalafil (PDE5 inhibitor) increases cGMP levels enhancing VEGFA expression, while low-dose rapamycin inhibits mTORC1 promoting autophagy-mediated stem cell maintenance. Combined therapy enhances angiogenesis via PECAM1+ endothelial cell proliferation and maintains stemness of tissue-engineered penile constructs.
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