Outcomes & management of peyronie’s disease (PD) with combined treatment of collagenase clostridium histolyticum (CCH) vacuum erection device (ED) and tadalafil
Abstract
Peyronie’s disease (PD) is a connective tissue disorder characterised by abnormal collagen deposition, leading to scarring of the tunica albuginea and causing penile curvature, pain, and erectile dysfunction (ED). Treatment options include medical and surgical interventions. This study evaluates the outcomes of a combined treatment regimen using Collagenase C. histolyticum (CCH), a vacuum erection device (VED), and tadalafil.
A retrospective observational study was conducted from January 2018 to January 2020, including 99 male patients with PD. Patients received CCH injections (4-8 doses), VED, and daily tadalafil (5 mg). Outcomes were assessed using the International Index of Erectile Function (IIEF) and changes in penile curvature. Patient satisfaction and complications were also documented.
The mean age of participants was 55.5 ± 9.8 years. The baseline mean penile curvature was 49.0° ± 20.4°, which improved by an average of 21.4% following treatment. A total of 44 patients received eight injections, while the remainder received four to six. Minor complications were observed in 15 patients, and 13 patients were dissatisfied with treatment, with six undergoing surgery. A significant improvement in IIEF scores (mean increase of 2.27 points, P < 0.001) was observed 4-6 months post-treatment.
This study suggests that combining CCH, VED, and tadalafil is a safe and effective approach for managing PD. The modified protocol showed significant improvements in penile curvature and…
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