Analyzing food supplements to enhance erectile system function for the presence of undeclared sildenafil and tadalafil using HPLC-dad
Abstract
Phosphodiesterase-5 (PDE-5) inhibitors, such as sildenafil and tadalafil,
are commonly used drugs to improve erectile function. However, some erectile
function-enhancing supplements with claims of being entirely natural may be
adulterated with these drugs, posing health risks. This study screened
supplements for erectile dysfunction from the Republic of North Macedonia
using a fast, specific, and sensitive HPLC-DAD method (runtime: 15 min). No
interference was observed at the retention times of sildenafil and
tadalafil, allowing for their unambiguous identification and quantification.
Tadalafil was absent, but sildenafil was found in two of eight samples
(32.78 mg and 13.47 mg per dosage). The results demonstrated the
applicability of the method to determine whether food supplements marketed
for erectile function enhancement are free of sildenafil and tadalafil.
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.