Low-Dose Tadalafil and Cabergoline versus Cabergoline alone in Management of Erectile Dysfunction in Patients with End-Stage Renal Disease and Hyperprolactinemia Undergoing Hemodialysis
Abstract
Background: Hyperprolactinemia in chronic kidney disease (CKD) is associated with high rates of hypogonadism and erectile dysfunction (ED). This study compares the efficacy, safety, and side effects of cabergoline monotherapy versus low-dose tadalafil combined with cabergoline in treating ED in end-stage renal disease (ESRD) patients undergoing hemodialysis with hyperprolactinemia. Patients and Methods: A total of 120 male ESRD patients on hemodialysis with ED and hyperprolactinemia were enrolled from November 2023 to December 2024 at Al-Azhar Hemodialysis Units, Cairo, Egypt. Patients were randomly assigned to two groups: Group 1 received 0.5 mg of cabergoline weekly, while Group 2 received 5 mg of tadalafil daily along with 0.5 mg of cabergoline. Efficacy was assessed using the International Index of Erectile Function-5 (IIEF-5) and hormonal assays for prolactin and testosterone after 6 weeks of treatment. Results: The combined Cabergoline/Tadalafil group showed a significant improvement in IIEF-5 scores (from 14.79 to 22.8, P<0.001), whereas the Cabergoline-only group showed no significant change. Prolactin levels decreased significantly in both groups (P<0.05), with no significant change in testosterone levels. Side effects were more common in the combined Cabergoline/Tadalafil group: 35% had back pain, 8.3% dizziness, and 48.3% headaches, compared to 11.6%, 1.7%, and 11.7%, respectively, in the Cabergoline-only group (P<0.05). Conclusion: Low-dose tadalafil combined…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 120 participants or records.
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.