Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria
Abstract
UNLABELLED: This study aimed to evaluate the genomic characteristics of Klebsiella spp. from human, animal, and food sources, and to establish their clonal relationships with globally circulating sequence types (STs). Using both phenotypic and next-generation sequencing approaches, a total of 300 samples comprising food samples (n = 180) and human clinical samples (n = 120) were collected and analyzed. Of these, 45 Klebsiella spp. were isolated from human (n = 16), animal (n = 15), and food (n = 14) sources. K. pneumoniae was the predominant species (34/45; 75.5%), followed by K. variicola subsp. variicola (4/45; 8.8%), K. quasipneumoniae (3/45; 6.6%), K. pneumoniae subsp. similipneumoniae (2/45; 4.4%), K. aerogenes (1/45; 2.2%), and K. michiganensis (1/45; 2.2%). Considering all the sources, 57.8 % of the isolates resulted in resistant to trimethoprim-sulfamethoxazole, while a lower percentage of strains showed resistance to aztreonam (17.8%), cefpodoxime (17.8%), cefotaxime (22.2%), ceftazidime (22.2%), ciprofloxacin (24.4%), colistin (15.6%), gentamicin (8.9%), levofloxacin (2.2%) and tobramycin (11.1%). In general, resistant strains were detected more frequently in samples of human and animal origin than in those of food origin. A total of 17 distinct STs were identified, including 9 novel STs. The fluoroquinolones resistance was mainly attributed to the presence of gene qnrS1 (33%), while strB (22%), strA (17.7%), and aac (6')-Ibr-cr (11.1%) for aminoglycoside. β-lactam…
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