How Lung Tissue Damage Improves by Moringa oleifera Leaves Extract in Rat Model Pneumonia
Abstract
Background: Pneumonia is an acute respiratory infection that causes a high mortality rate. Currently, there is an increasing problem of antibiotic resistance. Phytotherapy is one of the treatment choices for infectious diseases. Moringa oleifera extract is reported to have antibacterial, antioxidant, and anti-inflammatory functions. This study aimed to assess the effect of Moringa oleifera on tissue healing, inflammation, and lung infection in pneumonia rat models through molecular studies of colony-forming unit, Caspase-3 levels, and lung tissue necrosis. Methods: This is an experimental study using 40 male rats, randomly divided into 8 groups. Intranasal Klebsiella pneumoniae inoculation was carried out in groups B, C, D, E, F, G, and H. Subjects were divided into no treatment (A, B, C); levofloxacin 25mg (D); levofloxacin 25mg and Moringa oleifera 100mg (E); Moringa oleifera 100mg (F), 200mg (G), and 300mg (H). Termination and ELISA and histopathology examinations were carried out on day 5 for group C and day 14 for the others. Results: There is a significant effect of Moringa oleifera on improving tissue necrosis (p0,05). However, combination of levofloxacin 25 mg and Moringa oleifera 100 mg can reduce Caspase-3 levels and CFU. Conclusion: Moringa oleifera has a significant effect on reducing lung tissue necrosis in pneumonia rat models. Moringa oleifera can be considered as a complementary therapy to antibiotics for infectious diseases.
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