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Pay-It-Forward 23-Valent Pneumococcal Polysaccharide Vaccination Among Older Adults: Protocol for a Randomized Controlled Trial

Jiao Qin, Liang-Jia Wei, Chun-Xing Tao, Jinfeng He, Dan Wu, Zhifeng Lin, Ting Huang, Shiyu Qin et al.

JMIR Research Protocols, 2025

220 participants · 1 citation

Abstract

Background The 23-valent pneumococcal polysaccharide vaccine reduces the risk of pneumonia among adults by 38% to 46%. However, only a few older adults in resource-limited areas of China have received the pneumococcal vaccination. Pay-it-forward is a social innovation that offers participants free or subsidized health services and a community-engaged message, with an opportunity to donate to support subsequent recipients. Objective This study aims to assess the effectiveness and cost-effectiveness of the pay-it-forward intervention in encouraging the uptake of the 23-valent pneumococcal polysaccharide vaccine in adults aged ≥60 years. Methods A 2-arm, parallel randomized controlled trial will be conducted in 4 community health centers in Nanning city, Guangxi province, China. We will use a block randomization design. A total of 204 older adults will be randomly allocated in a 1:1 ratio to either the pay-it-forward group or the standard-of-care group. Each participant will complete a web-based questionnaire. The standard-of-care group will be required to pay for the vaccine themselves. In contrast, the pay-it-forward group will receive a 150 RMB (US $20.7) vaccination subsidy, postcards, and the opportunity to donate. The participants in both groups will be followed up in the second and fourth weeks after enrollment. The primary outcome will be uptake of the 23-valent pneumococcal polysaccharide vaccine, as determined by administrative data. Secondary outcomes include costs,…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 220 participants or records.

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