Characteristics and influencing factors of bronchoalveolar lavage fluid cellular patterns in children with Mycoplasma pneumoniae pneumonia: a cross-sectional study
Abstract
Background Mycoplasma pneumoniae pneumonia (MPP) is a common cause of community-acquired pneumonia in children. Clinical assessment currently relies mainly on blood inflammatory markers. Bronchoalveolar lavage fluid (BALF) cellular analysis provides an important window to directly assess local pulmonary inflammation. Small studies have demonstrated BALF neutrophil predominance in pediatric MPP. However, large-scale studies on the characteristics and influencing factors of BALF cellular patterns are lacking. In particular, it remains unclear whether local MP-DNA load independently associates with neutrophil predominance or whether common blood inflammatory markers correlate with BALF cellular patterns. This large cross-sectional study aimed to characterize BALF cellular patterns and investigate influencing factors. Methods This single-center cross-sectional study consecutively enrolled children with confirmed MPP (positive BALF MP-DNA) hospitalized at Tianjin Children’s Hospital from November 2023 to April 2024. Diagnosis followed the Chinese Guidelines for the Diagnosis and Treatment of Mycoplasma pneumoniae Pneumonia in Children (2023 Edition). BALF cytological examination were performed in accordance with the Consensus of Chinese Experts on Morphological Examination of Bronchoalveolar Lavage Fluid Cells [2023]. Clinical and laboratory covariates were extracted from medical records. Spearman’s rank correlation, Kruskal-Wallis H test, Mann-Whitney U test and multivariable…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 238 participants or records.
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