C50-31 Extracorporeal Life Support for Severe Adenovirus Pneumonia-induced Acute Respiratory Distress Syndrome in an Immunocompetent Adult
Abstract
Human adenoviruses, belonging to the Adenoviridae family, are non-enveloped, double-stranded DNA viruses that typically cause self-limiting respiratory, gastrointestinal, or conjunctival infections in immunocompetent individuals. Although severe adenoviral infections are more frequently observed in immunocompromised hosts, they can occasionally occur in immunocompetent individuals and may even result in fatal outcomes. Here, we report a rare case of severe adenovirus pneumonia in an immunocompetent adult that progressed to acute respiratory distress syndrome and required extracorporeal life support.
A 34-year-old woman with a history of asthma and major depressive disorder presented with a four-day history of fever, chills, productive cough with yellowish sputum, and diarrhea. She denied smoking, recent travel, or contact with sick individuals. Empirical antibiotics prescribed at an outpatient clinic provided no improvement. Upon arrival at the emergency department, she was febrile and tachycardic. Chest radiography revealed consolidation in the left lower lobe. Laboratory evaluation showed a white blood cell count of 5,100/µL (neutrophils 85.5%, lymphocytes 9.6%), hemoglobin 13.6 g/dL, platelet count 198,000/ µL, C-reactive protein 10.13 mg/dL, and alanine transaminase 60 U/L. She was admitted with a diagnosis of community-acquired pneumonia and initiated on levofloxacin and piperacillin-tazobactam. Her respiratory status deteriorated rapidly over the following three days,…
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