Levofloxacin Adsorption and Release on γ-Mesoporous Alumina Nanoparticles Using Linear Kinetics Equations
Abstract
Mesoporous alumina is a promising drug carrier because of its extensive surface area, pore structure, biocompatibility and non-toxicity, facilitating high drug loading and release capacity. This study aimed to investigate the adsorption and release kinetics of levofloxacin (LF) on prepared γ-mesoporous alumina nanoparticles (γ-MNPs). Adsorption kinetic tests were carried out by a batch method, drug loading was investigated using an impregnation method, and the release kinetics were determined using a dialysis bag maintained at 310 K. Adsorption kinetics were analysed using three kinetics models: the pseudo-first-order, pseudo-second-order and intraparticle diffusion. Results showed that the adsorption of LF followed a pseudo-second-order reaction, with the adsorption rate and mechanisms regulated by two consecutive steps, suggesting that intraparticle diffusion was involved, but it was not the only rate-controlling step. Drug loading results showed that the amount of LF loaded into γ-MNP was 2.17 mg drug/g γ-MNP. The drug release behaviour was investigated at pH 7.4 and pH 5.4. The drug release profile for the LF/γ-MNP system showed that the drug release percentages were 18.00% at pH 5.4 after 48 h and 90.41% at pH 7.4 after 24 h. Drug release was characterised by the kinetic models, including zero-order and first-order kinetics. The data from the pH 5.4 system was best fitted by zero- and first-order kinetics. The drug release mechanisms from a matrix were interpreted using…
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