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Crystal structure and Hirshfeld surface analysis of anhydrous salt of levofloxacin and 4-methylbenzoic acid

Bhumiben Chandubhai Patel, Krunal Modi, J. Prakasha Reddy

Acta Crystallographica Section E Crystallographic Communications, 2025

Abstract

The anhydrous salt levofloxacinium 4-methylbenzoate, C 18 H 21 FN 3 O 4 + ·C 8 H 7 O 2 − , has been synthesized and its crystal structure determined. In the crystal, the levofloxacinium ions interact with the 4-methylbenzoate anion via N—H + ...O − and C—H...O hydrogen bonds, forming a tape-like supramolecular structure. Hirshfeld surface analysis and the calculated two-dimensional finger plots of the various atom–atom contacts involving both the ions are described.

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