P-1182. In Vitro Activity of Omadacycline and Comparator Agents Against Periodontal Pathogens
Abstract
Abstract Background Omadacycline is a tetracycline class aminomethylcycline antibiotic FDA-approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections in adults (IV or oral). Omadacycline has broad spectrum antibacterial activity against Gram-positive and -negative bacteria, including aerobic, anaerobic and atypical bacteria, and has demonstrated immunomodulatory properties. The objective of this study was to evaluate omadacycline activity against common periodontal pathogens. Severe periodontal disease, inflammation of tissues around the teeth, is estimated by the World Health Organization to affect more than a billion people worldwide. In certain cases, antibiotics are prescribed as adjunct therapy to minimize infection and decrease inflammation, with the most common being tetracyclines, metronidazole, fluoroquinolones, amoxicillin, and macrolides. Methods Broth microdilution was performed according to CLSI against aerotolerant streptococci and Actinomyces spp. that were able to grow in 5% CO2 atmosphere. Agar dilution was performed according to CLSI for anaerobes. Omadacycline and comparators tetracycline, meropenem, levofloxacin and metronidazole were evaluated against 63 clinical isolates collected from New York, Indiana, Illinois, and California from 2009 to 2018 and 10 ATCC strains. In total, 73 isolates were evaluated across 8 genera: Streptococcus, Actinomyces, Treponema, Fusobacterium, Parvimonas,…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.