P-1100. Activity of Cefiderocol and Comparator Agents Against Global Isolates of Stenotrophomonas maltophilia from the SENTRY Antimicrobial Surveillance Program (2020–2023)
Abstract
Abstract Background Stenotrophomonas maltophilia is a ubiquitous multidrug-resistant opportunistic pathogen. Infections caused by S. maltophilia have limited antibiotics treatment options due to the intrinsic resistant mechanisms such as the production of chromosomal L1 metallo-type carbapenemase and L2 extended-spectrum type β-lactamase. Cefiderocol (FDC) is a siderophore-conjugated cephalosporin with broad activity against Gram-negative bacteria, including S. maltophilia. In this study, the in vitro activities of cefiderocol and comparators were investigated against S. maltophilia clinical isolates that were collected from the US and Europe in 2020-2023 as part of the SENTRY Antimicrobial Surveillance Program. Susceptibility of Stenotrophomonas maltophilia to cefiderocol and comparator agents Cefiderocol (FDC), levofloxacin (LVFX), trimethoprim-sulfamethoxazole (TMP-SMX), minocycline (MIN), ceftazidime (CAZ), imipenem-relebactam (I/R), ceftazidime-avibactam (CZA), non-susceptible (NS), susceptible (S), intermediate (I), resistant (R), N/A (not applicable), a cefiderocol S ≤1, levofloxacin S ≤2, trimethoprim-sulfamethoxazole S ≤2/38, minocycline S ≤1, breakpoints as published by CLSI (2024), b cefiderocol S ≤2, levofloxacin S ≤0.5, ceftazidime S≤4, imipenem-relebactam S ≤2, ceftazidime-avibactam S ≤8, PK-PD breakpoints as published by EUCAST (2023) Methods A total of 1782 S. maltophilia isolates were consecutively collected from the US and Europe from 2020-2023. The most…
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