Carbapenem-resistant Acinetobacter baumannii from Jordan: Complicated carbapenemase combinations
Abstract
Acinetobacter baumannii is an opportunistic Gram-negative bacterium that has recently emerged as a clinically important pathogen.It is the most common Acinetobacter species associated with hospital-acquired infections worldwide.This study aimed to investigate the resistance characteristics of clinical carbapenem-resistant A. baumannii isolates from Jordanian hospitals.Between May 2018 and May 2019, a total of 190 isolates of Acinetobacter were collected from patients diagnosed with upper respiratory tract infection (47.5%), sepsis (15.4%), skin infection (14.2%), bronchitis (8.6%), urinary tract infection (4.3%), meningitis (3.7%), diabetes (2.5%), necrotizing fasciitis (1.9%), and cancer, peritonitis, and pneumonia (0.6% each) from seven Jordanian hospitals.Vitek GN ID Cards were employed to identify them, and the identification was validated by the detection of Acinetobacter spp.recA gene (100%), A. baumannii intergenic spacer region (85.3%), and the A. baumannii rpoB gene (85.3%).The Vitek AST-N222 and AST-XN05 cards were utilized to determine the minimum inhibitor concentration for a variety of antibiotics including Gentamicin, Tobramycin, Piperacillin-tazobactam, Ticarcillinclavulanic acid, Ticarcillin, Imipenem, Meropenem, Cefepime, Ceftazidime, Ceftriaxone, Ciprofloxacin, Levofloxacin, Trimethoprim-sulfamethoxazole, Piperacillin, Minocycline, and Tetracycline.The E-test was performed to evaluate the effectiveness of Colistin against all A. baumannii isolates.According…
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