Randomized comparative study of levofloxacin and amoxicillin/clavulanate plus clarithromycin in treatment of patients with community-acquired pneumonia
Abstract
Objective To compare the clinical effects of levofloxacin and amoxicillin/clavulanate plus clarithromycin in treatment of patients with community acquired pneumonia(CAP).Methods Sixty patients with CAP were randomly divided into levofloxacin group(group A) and amoxicillin/clavulanate plus clarithromycin group(group B),respectively and each group consisted of 30 patients.Group A received 500 mg IV q24h transitioning to oral levofloxacin 500 mg q24h when the patients' conditions were changed.Group B received amoxicillin/clavulanate 500 mg/100 mg IV q8h with oral clarithromycin 500 mg q12h and then switched to oral amoxicillin/clavulanate 250 mg/125 mg q8h with oral clarithromycin 500 mg q12h.The course of treatment was taken for a total of 7 to 14 days.Results The total effective rates of group B and group A were 93.3% and 96.7%;the bacteria eradication rates were 73.3% and 60.0% respectively,and there were no statistically significant difference(P 0.05).The adverse reactions of two groups were slight and there was no statistically significant difference(P 0.05).Conclusion It is safe and good for levofloxacin and amoxicillin/clavulanate plus clarithromycin for treatment of patients with CAP,and they all can be used as first choice drugs of CAP.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 30 participants or records.
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