2019 ACCP Annual Meeting
Abstract
Introduction: Hyponatremia, as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), is well known with the use of nearly all antipsychotics.Information available about the risk of hyponatremia associated with paliperidone is limited.Research Question or Hypothesis: To report a fatal case of hyponatremia secondary to SIADH associated with the use of paliperidone, systematically review the literature for the association of hyponatremia/ SIADH with paliperidone and to quantify in reporting risk for this association in FAERS.Study Design: Retrospective case/non-case analysis Methods: Case data was collected during routine pharmacovigilance activity.A systematic literature search for paliperidone-induced Hyponatremia/ SIADH was carried out in the MEDLINE and EMBASE databases.Case/non-case analysis of the FAERS database concerning paliperidone-induced hyponatremia/SIADH was conducted.Reporting risk was quantified by a measure of disproportionality using the reporting odds ratio (ROR) while adjusting for sex, age and concomitant medications associated with hyponatremia/ SIADH.Results: A 39-year-old female patient with an 8-year history of bipolar disorder recently started on Paliperidone presented in an unconscious state with hypothermia, and asystole.Biochemical analysis and family history patient had primary polydipsia, projectile vomiting and secondarily developed hyponatremia.Emergent cerebral computed tomography scan was evident for marked cerebral…
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