Antimicrobial photodynamic therapy effects mediated by methylene blue in surfactant medium as an adjuvant treatment of teeth with apical periodontitis and presence of fistula-Protocol for randomized, controlled, double-blind clinical trial
Abstract
Objective: This study aims to evaluate the efficacy of photodynamic therapy as an adjunct to conventional endodontic treatment in patients with apical periodontitis and fistulas. In this study, a fistula is characterized as a pathological conduit originating from the infected region at the root apex of the tooth, traversing the oral mucosa, and extending to the external surface of the gingiva. This pathological condition frequently complicates the management of endodontic infections, thereby necessitating the evaluation of supplementary therapeutic interventions. The standard treatment for endodontic infections involves thorough disinfection of the root canal system to remove microbial contamination from the canal and surrounding tissues. To potentially augment the efficacy of conventional treatment, aPDT is proposed as a supplementary, non-invasive technique. This innovative technique uses a photosensitizer, which is a light-sensitive dye, in combination with a light source to produce reactive oxygen species. Reactive oxygen species can effectively target and eliminate bacteria in the root canal system, potentially enhancing treatment outcomes.
Methods: The study will involve 140 teeth with apical periodontitis and fistulas. The teeth will be randomly assigned to one of two treatment groups. Group I will receive only the conventional endodontic treatment, which includes root canal cleaning, shaping, and obturation. Group II will undergo the same conventional endodontic…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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