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Innovative Designs of Multimodal Imaging Based on Radionuclide, Quantum, and Cargo-Loaded Nanoplatform Emitters Towards Enhanced Energy–Matter Interactions for Photonics and Bioassays

M. Romero, D. Quinteros, A. Bracamonte

Materials, 2026

Abstract

Highlights Generation of multimodal imaging. Application of radionuclides and tracers. Cargo-loaded nanoplatforms for multi-functional applications. Design of new optical set-ups incorporating enhanced nano-optics. Development of nanophotonics towards photonics applications. Abstract This mini-review is intended to show how multimodal imaging could be developed from prototypes and proofs of concept by controlling the nanoscale for improved resolution of life science imaging for broad applications such as bioassays, early diagnoses and further applications. It intends to afford the presentation of multimodal approaches for imaging and bioimaging uses with potential applications to biological media. The application of multimodal nanoemitters provides enhanced bioimaging through the generation of various targeted and well-defined signals. Radionuclides and luminescent emitters were considered in the discussion for improved and enhanced signaling. In this manner, we intended to show the increase in the power of information by collecting varied optical signal–matter interactions. This could be important for Positron Emission Tomography and Computed Tomography (PET-CT), Fluorescence Tomography (FT), and other new modes of imaging contemplating the incorporation of nanotechnology. In the context of the design of new multimodal energy modes, key examples were shown from the literature, where the interactions of different energy modes could lead to enhanced and improved signaling.…

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