From bone replacement to regeneration. A biomaterials started journey
Abstract
Over the past decades, strategies for skeletal repair have undergone a significant transformation, shifting from inert structural replacements to advanced systems capable of actively promoting bone regeneration. Early biomaterials, including metals and bioinert ceramics, were designed primarily to provide mechanical support with limited biological interaction. With increasing knowledge of bone physiology and healing processes, bioactive and osteoconductive materials such as hydroxyapatite and calcium phosphate ceramics emerged to enhance integration and stimulate new tissue formation. Modern regenerative biomaterials are now engineered to emulate essential features of the extracellular matrix, deliver precisely controlled biological cues, and interact dynamically with cells to drive osteogenesis, angiogenesis, and tissue remodeling. Biomaterial-based approaches help overcome the major drawbacks of autografts and allografts, including donor-site complications, restricted supply, and immunological concerns. Advances in polymers, ceramics, hydrogels, and composite scaffolds, together with emerging technologies such as 3D bioprinting and controlled growth factor delivery, allow improved regulation, and direct comparison, of mechanical performance, degradation behaviour, and bioactive signalling. This broader perspective is further strengthened by the integration of key aspects of biomaterial-clinical translation, including major translational barriers, current clinical outcomes,…
Read the paper
Related studies
- Chaos and quantum thermalization
- The Dalton quantum chemistry program system
- Quantum dots: synthesis, bioapplications, and toxicity
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study
- A Guide to In Silico Drug Design
- Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.