OC-0538: Daily versus weekly prostate cancer image-guided radiotherapy: A Phase 3 randomized trial
Abstract
Purpose Objective The optimal frequency of prostate cancer image-guided radiation therapy (IGRT) has not yet been clearly identified. This study sought to compare the safety and efficacy of daily versus weekly IGRT. Total ranged from 70 to 80 were randomly assigned to two prostate IGRT control frequency groups: daily or weekly (Days 1, 2, and 3, then weekly). The primary was 5-year recurrence-free survival (RFS). Secondary outcomes included overall survival (OS) and toxicity (CTCAE V.3.0). Post-hoc analyses included biochemical progression-free interval (BPFI), clinical progression-free interval (CPFI) and second cancer-free interval (SCFI). Abstract text Cancer genetics tells us that each person’s cancer is as unique as their fingerprints, creating an opportunity for personalised treatment, but which has never been delivered. Our in-depth understanding of the biology of cancer has so far given rise to targeted agents of only Abstract text The ESTRO-HERO project has shown that there is a huge variation in equipment and staffing levels across Europe. A considerable variation also in delivered courses per year is evident among the highest and lowest staffing levels, reflecting the variation in cancer incidence and socio-economic determinants, as well as the Abstract text This presentation will not elaborate further on the so-called 2 souls of medical physics as it was nicely stated in an editorial of Radiotherapy and Oncology in 2015, referring to the difficult balance between…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Quantum dots: synthesis, bioapplications, and toxicity
- A Guide to In Silico Drug Design
- Quantum Computing for Healthcare: A Review
- Automated in Silico Design of Homogeneous Catalysts
- Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
- In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.