Neon ion radiotherapy: physics and biology
Abstract
Neon ion (20Ne) beam radiotherapy was one of the primary particle therapy candidates investigated during the clinical trials beginning in the 1970s at the Lawrence Berkely National Laboratory (LBNL), which shut down in the early 1990s. Currently, therapeutic neon ion beams are available at only one clinical facility worldwide, the National Institutes for Quantum Science and Technology (QST) in Chiba, Japan. Recently, neon ion beams were commissioned at QST Hospital as part of the first clinical multi-ion therapy (MIT) program, which aims to improve clinical outcomes by escalating higher linear energy transfer (LET) radiation in the tumor for treating therapy-resistant disease. With the advancement of high-precision scanning delivery techniques, neon ion treatments in the present day could be delivered more safely and with greater precision compared to the first and only clinical application decades prior at LBNL using passive scattering technology. Despite their promising results, preclinical investigations of neon ions are scarce outside of Japan and further independent studies are needed. Clinically, neon ion therapy may offer benefits in treating certain malignancies by escalating LET in the tumor, but its limited availability and high costs restrict its current use and adoption. Studies have shown that 20Ne or multi-ion mixtures (4He, 12C, 16O and/or 20Ne) can provide larger degrees of freedom in optimization of dose, LET and relative biological effectiveness, otherwise…
Read the paper
Related studies
- Quantum dots: synthesis, bioapplications, and toxicity
- A Guide to In Silico Drug Design
- Quantum Computing for Healthcare: A Review
- Automated in Silico Design of Homogeneous Catalysts
- Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
- In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.