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Secure near-lossless medical image compression and encryption with image-specific post-quantum key management and blockchain-based verification

Yadav B, Arakeri M

PloS one, 2026

Abstract

Secure image transfer is a critical requirement in telemedicine and Picture Archiving and Communication Systems (PACS), where diagnostic integrity and patient confidentiality must be simultaneously ensured. High-resolution medical images, especially Magnetic Resonance Imaging (MRI), are often transferred over bandwidth-limited networks without impairing diagnostic quality or confidentiality against unauthorized access, manipulation, and replay. Existing approaches generally rely on a cascaded pipeline where image compression, encryption, and verification are considered as separate, independent operations. These distributed designs are prone to cryptographic key management issues, suffer from non-deterministic error control, lack meaningful coupling between image identity and cryptographic state, and provide no verifiable provenance or post-quantum key migration support. In this paper, we propose a DICOM-compliant system that integrates [Formula: see text]-regularized near-lossless image compression, hyperchaotic permutation diffusion encryption, post-quantum secure key establishment, and blockchain-based provenance verification as a unified operation. JPEG 2000 is used for primary image compression, and a residual refinement layer is introduced to limit residual correction amplitudes by [Formula: see text]-regularization to retain diagnostically significant information. Hyperchaotic encryption is performed with a symmetric image key generated using the NIST-standard…

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