Adjunctive melatonin and sildenafil, enhances antioxidant defense in metformin-treated polycystic ovary syndrome patients: A randomized study
Abstract
Objective: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, the exact causes of which are still not known. However, studies have emphasized the role of oxidative stress in the pathogenesis of PCOS. The aim of this study is to investigate the effect of sildenafil and melatonin on oxidative stress markers in PCOS patients.
Study design: 51 PCOS patients were randomly divided into three groups and received treatment for three months. Group 1, only received metformin; Group 2, received melatonin + metformin, and Group 3 received sildenafil + metformin. Blood samples were collected before and after the treatment started, and serum levels of malondialdehyde (MDA), nitric oxide (NO), ferric-reducing antioxidant power (FRAP), protein carbonyl (PC) and total thiol (T-SH) were measured.
Result: The findings of the study demonstrated a decline in the mean levels of MDA and PC in the metformin-only, sildenafil, and melatonin groups. This decline was statistically significant for MDA in the metformin-only group (P=0.008) and the sildenafil group (P=0.04), and for PC in the metformin-only group (P=0.005) and melatonin group (P=0.04). The antioxidant markers such as T-SH (P=0.009) and FRAP (P=0.03) levels significantly increased in the melatonin group after the intervention.
Conclusion: Overall, biomarkers of oxidative stress improved in the metformin-only, melatonin, and sildenafil groups, suggesting that these drugs may have protective effects in PCOS…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 51 participants or records.
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