Amplification of Secondary Flow at the Initiation Site of Intracranial Sidewall Aneurysms
Abstract
The initiation of intracranial aneurysms has long been studied, mainly by the evaluation of the wall shear stress field. However, the debate about the emergence of hemodynamic stimuli still persists. This paper builds on our previous hypothesis that secondary flows play an important role in the formation cascade by examining the relationship between flow physics and vessel geometry. A composite evaluation framework was developed to analyze the simulated flow field in perpendicular cross-sections along the arterial centerline. The velocity field was decomposed into secondary flow components around the centerline in these cross-sections, allowing the direct comparison of the flow features with the geometrical parameters of the centerline. Qualitative and statistical analysis was performed to identify links between morphology, flow, and the formation site of the aneurysms. The normalized mean curvature and curvature peak were significantly higher in the aneurysmal bends than in other arterial bends. Similarly, a significant difference was found for the normalized mean velocity (p=0.0274\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p=0.0274$$\end{document}), the circumferential (p=0.0029\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts}…
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