Efficacy of mixture of injectable-platelet rich fibrin and type-1 collagen particles on the closure of through-and-through periapical bone defects - A randomized controlled trial
Abstract
AIM
To determine the efficacy of a combination of injectable-platelet rich fibrin and type-1 collagen particles on the healing of through-and-through periapical bone defect and subsequent closure of bony window.
METHODOLOGY
The clinical trial was registered in ClinicalTrials.gov(NCT04391725). Thirty eight individuals with radiographic evidence of periapical radiolucency in maxillary anterior teeth and confirmed loss of palatal cortical plates in cone beam computed tomographic imaging were randomly assigned to either experimental group(n=19) or the control group(n=19). Mixture of i-PRF and collagen as a graft was applied to the defect in adjunct to periapical surgery in experimental group. No guided bone regeneration procedures were used in the control group. The healing was evaluated using Molven's(2D) and modified PENN 3D(3D) criteria. Percentage reduction of the buccal and palatal bony window area, and complete closure of through-and-through periapical bony window (tunnel defect) were assessed using Radiant Diacom viewer software(Version 4.0.2). The reduction in the periapical lesion area and volume was measured using Corel DRAW and ITK Snap software.
RESULTS
Thirty four participants(18 and 16 in the experimental and control group, respectively) reported for follow-up at 12 months. There was 96.9% and 97.96% reduction of buccal bony window area in experimental and control groups respectively. Similarly, palatal window showed 99.03% and 100% reduction in experimental and…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 19 participants or records.
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