Platelet-rich plasma enhances bone union in posterolateral lumbar fusion: A prospective randomized controlled trial
Abstract
BACKGROUND CONTEXT
Platelet-rich plasma (PRP) accelerates bone union in vivo in a rodent model of spinal fusion surgery. However, PRP's effect on bone union after spinal surgery remains unclear.
PURPOSE
The objective of this study was to evaluate the efficacy of PRP after posterolateral lumbar fusion (PLF) surgery.
STUDY DESIGN/SETTING
Single-center prospective randomized controlled clinical trial with 2-year follow-up.
PATIENT SAMPLE
The patient sample included a total 62 patients (31 patients in the PRP group or 31 patients in the control group).
OUTCOME MEASURES
The outcome measures included the bone fusion rate, the area of bone fusion mass, the duration of bone fusion, and the clinical score using the visual analog scale (VAS).
MATERIALS AND METHODS
We randomized 62 patients who underwent one- or two-level instrumented PLF for lumbar degenerative spondylosis with instability to either the PRP (31 patients) or the control (31 patients) groups. Platelet-rich plasma-treated patients underwent surgery using an autograft bone chip (local bone), and PRP was prepared from patient blood samples immediately before surgery; patients from the control group underwent PLF without PRP treatment. We assessed platelet counts and growth factor concentrations in PRP prepared immediately before surgery. The duration of bone union, the postoperative bone fusion rate, and the area of fusion mass were assessed using plain radiography every 3 months after surgery and by computed tomography at…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 62 participants or records.
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