Functional brain network organization during the 40-Hz auditory steady-state response in children with and without autism spectrum disorder
Abstract
Introduction: The auditory steady-state response (ASSR) at 40 Hz provides a well-established probe of gamma-band neural synchronization and is thought to reflect excitation-inhibition balance in cortical microcircuits-a mechanism implicated in autism spectrum disorder (ASD). Previous studies focusing on regional ASSR measures have yielded inconsistent findings for ASD, suggesting that system-level approaches may provide complementary information about ASD-related neurophysiological alterations.
Methods: We examined source-level functional brain networks during the 40-Hz ASSR in children with ASD (n = 19) and typically developing (TD) children (n = 34) aged 5-8 years using magnetoencephalography (MEG). Functional connectivity was estimated using the phase lag index (PLI) within the 30-50 Hz band, and graph-theoretical metrics-clustering coefficient (CC), characteristic path length (PL), and small-worldness (SW)-were computed from binary undirected networks. Group differences were assessed using multiple linear regression adjusting for age, sex, and cognitive ability. Associations between network measures and autistic traits, indexed by the Social Responsiveness Scale (SRS), were examined using a regression model including diagnosis and the interaction of diagnosis × graph measure.
Results: The experimental paradigm elicited ASSR-related cortical activity in both groups. A significant main effect of diagnosis was observed for characteristic PL, with children with ASD…
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