Hybrid classical and quantum computing for enhanced glioma tumor classification using TCGA data
Abstract
Gliomas are the most prevalent malignant primary brain tumors and present diagnostic challenges due to varying survival rates and treatment responses between low-grade gliomas (LGGs) and high-grade gliomas (HGGs). Accurate classification is crucial for effective treatment and prognosis. While classical AI methods have shown promise in glioma classification, the growing volume of medical data, inherent noise, and limitations of classical vector spaces present significant challenges. However, quantum computing-based AI methods have the potential to process data in parallel by leveraging quantum properties such as superposition and entanglement, analyze higher-dimensional data more efficiently, and solve certain problems that classical methods struggle with more rapidly and effectively. This study introduces a novel hybrid classical and quantum computing model to distinguish LGGs from HGGs using data from The Cancer Genome Atlas (TCGA). In the classical part, an ensemble feature selection method was employed to identify the most informative molecular markers and clinical features in the TCGA. In the quantum component, six variational quantum classifier (VQC) models with varying hyperparameters were evaluated. These classifiers utilize selected features to differentiate LGGs from HGGs. Among these, the VQC-1 model, which employs \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}…
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