The Discovery of Antibacterial Cembranoids from the Soft Coral Lobophytum crassum by DeepSAT Analysis
Abstract
Eight previously unreported cembranoids (1-8), along with four known ones (9-12), have been isolated and identified from the soft coral Lobophytum crissum collected from the South China Sea under the guidance of HSQC-based DeepSAT analysis for targeted isolation. The structures of the new compounds were determined by comprehensive spectroscopic analysis, QM-NMR, TDDFT-ECD calculations, and comparison with reported literature data from analogs. In in vitro bioassays, all the isolated compounds have been screened for their antibacterial and antiproliferative activities.
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