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Hybridized Quantum Computing and Federated Learning for Multi-Disease Prediction

A. S., A. M., B. S, Gowtham

International Journal of Innovative Science and Research Technology, 2026

Abstract

The growing occurrence of patients with multiple chronic diseases has increased the need for efficient multidisease risk prediction systems in healthcare. However, clinical data is often distributed in various cloud, but it lacks in

efficient privacy preservation. To address these challenges, this project proposes a hybridized framework for privacy-aware

multi-disease risk prediction in distributed healthcare environments. nA key challenge in multi-disease data collection from

heterogeneous clinical data may lag in normalization. So, cleaning and preprocessing is done on the first phase. Second

challenge lies in capturing complex and non-linear relationships among clinical features within reduced feature spaces. To

handle this, quantum-inspired feature encoding and variational quantum circuits are employed to enhance feature

representations. Since data is distributed across cloud data privacy and confidentiality issues exist. To overcome this issue

Federated Learning for multi-disease prediction is applied in the third phase. To address these challenges, this paper

proposes a novel framework titled Hybridized Quantum Computing and Federated Learning for Multi-Disease Prediction

(HQCF-MDRP). The proposed system integrates structured data preprocessing, quantum-assisted feature representation,

and federated collaborative learning into a unified architecture. Initially, healthcare datasets are cleaned, normalized, and

subjected to feature selection to improve data quality and…

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