Quantum Computing Empowers Protein Engineering: The Chinese Path from Discovery to Rational Design
Abstract
酶工程正在从一门经验学科逐步转变为计算驱动的科学。然而，传统计算方法仍受限于电子结构计算与序列优化中存在的指数级复杂度，制约了高精度、高效率新型酶的设计与开发。量子计算的出现为解决这一难题带来了突破性可能：利用量子比特的叠加与纠缠特性，量子算法在处理复杂分子问题时具备指数级加速潜力，有望引领酶工程领域的范式变革。本文综述了近年来量子算法在酶设计中的应用进展，量子计算与酶设计融合的历史演进，比较了国际与中国在量子计算领域的发展态势，并着重分析了中国在硬件创新、产业生态构建与战略协同方面的独特优势。在此基础上，我们提出以“硬件突破、产业驱动、战略引领”为核心的集成发展框架，将酶工程确立为量子计算的重要应用方向，从而推动该技术从理论验证走向产业落地。
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