Chapter 12: Artificial Intelligence and Quantum Computing for the Design of Novel Kisspeptin-10 Analogues and Their Experimental Evaluation in Cervical Cancer Cells
Abstract
Cervical cancer remains a leading cause of morbidity and mortality in women, underscoring the need for innovative therapies.Kisspeptin-10 (KP10), a decapeptide that activates the G-protein-coupled receptor (GPCR) Kiss1R, shows antitumour potential.Using artificial intelligence (AI) based modelling, a focused library of KP10 analogues was designed; 10 top candidates were synthesised and evaluated.Molecular docking predicted enhanced Kiss1R affinity, which was confirmed in vitro by MTT and wound-healing assays in cervical cancer cells.Several analogues showed superior cytotoxicity and migration inhibition versus KP10.These results highlight AI-assisted peptide design as an efficient approach for developing GPCR-targeted therapeutics in cervical cancer.
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