Investigation of Therapy Response With Amino Acid Analogue Transport PET Imaging
Abstract
The purpose of this study is to assess if using anti-1-amino-3-\[18F\]fluorocyclobutane-1-carboxylic acid (FACBC or fluciclovine) PET scan will be useful in determining if participants are responding to chemotherapy treatment. Investigators will enroll participants whose cancer has been treated with hormone therapy and now the cancer is not responding to the treatment (castration -resistant), and so therefore will be started on chemotherapy. Investigators aim to enroll thirty participants in this study.
Conditions: Prostate Cancer.
Primary outcome: Percent Change Assessed by FACBC PET Scan; Prostate Specific Antigen Level; Number of Participants Responding to Treatment Assessed by MRI; Number of Participants Responding to Treatment Assessed by CT Scan; Number of Participants With a Clinical Response Assessed by Bone Scan.
Enrollment: 7 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 7 participants or records.
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