Meta-analytical analysis on oxidative stress caused by micro- and nanoplastics in different life stages of Danio rerio
Abstract
Microplastics, known for being persistent and widespread, are environmental small particles that have the potential to be considered as pollutants with different aspects of stress in the environment. This review is a meta-analysis based on 50 articles (2016-2023) with 403 estimations examining the relationship between exposure to micro- and nanoplastic particles (MP/NP) and oxidative stress in Danio rerio (zebrafish) in both larval and adult life stages. Results indicate that exposure to MP/NP may induce changes in markers of oxidative stress. Notably, a general decline in Glutathione Peroxidase (GPx) activity as well as an elevation in Reactive Oxygen Species (ROS) was identified. While GPx activity was diminished in adults and larvae, CAT activity was decreased only in adults and was unaltered in larvae. Glutathione S-transferase (GST) activity increased in adults but decreased in larvae. MDA content remained unchanged in adults but decreased significantly in larvae. ROS levels consistently demonstrated an increasing pattern in both life stages, and no significant alterations were detected in Superoxide Dismutase (SOD) activity and GSH levels. Tissue-specific analyses in adult D. rerio demonstrated diverse results, with reduced CAT in the brain and GPx in the gills, and increased GST in gills and liver, and enhanced ROS production in brain, gills, and liver. It seemed that different types of plastic (polystyrene and polypropylene) could induce different enzymatic profiles.…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Preliminary Toxicity Analysis of 3DCRT versus IMRT on the High Dose Arm of the RTOG 0126 Prostate Cancer Trial
- Adaptive Radiotherapy for Head and Neck Cancer: Initial Clinical Outcomes from a Prospective Trial
- American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology
- Motion Management Strategies and Technical Issues Associated with Stereotactic Body Radiotherapy of Thoracic and Upper Abdominal Tumors: A Review from NRG Oncology
- High-dose-rate interstitial brachytherapy as a monotherapy for localized prostate cancer: treatment description and preliminary results of a phase I/II clinical trial
- Highly efficient training, refinement, and validation of a knowledge-based plan quality control system for radiotherapy clinical trials
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.