Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis
Abstract
Introduction: Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging modality that enables estimation of temporal changes in radiopharmaceutical distribution and physiological function. While dynSPECT has been employed in several clinical applications, it has not been widely applied to liver imaging. This review aims to investigate the role and effectiveness of dynSPECT in assessing hepatic function.
Methods: Following PRISMA guidelines, literature searches were conducted in MEDLINE, PubMed, Scopus, Embase, IEEE, and Web of Science, including all publications available up to December 2025 that assessed liver function using dynSPECT imaging, standard laboratory function tests and clinical scoring systems. Search results were screened by two authors. Included studies were assessed for bias using the QUADAS-2 quality assessment test tool.
Results: Sixteen eligible studies were incorporated in this review, involving 715 participants, of whom 87% (624) had hepatic diseases. Meta-analysis revealed correlations between dynSPECT measures of liver function and the laboratory tests, including Hepaplastin (r = 0.5471; 95% CI: 0.4523 to 0.6418), Indocyanine Green (ICG) (r = -0.461; 95% CI: -0.831 to -0.081), and Bilirubin (r = -0.425; 95% CI: -0.714 to -0.14). Furthermore, the comparison between the two dynSPECT parameters and clinical scoring systems, including the Child-Pugh score, MELD, and the histologic activity index (HAI), has a…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 715 participants or records.
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