Efficacy of eyelid warming therapies in contact lens-related dry eye and comfortable wearing time: a systematic review with meta-analysis
Abstract
Purpose: To analyse the efficacy and safety of eyelid warming therapies in the management of contact lens-related dry eye (CLDE) and their impact on comfortable contact lens (CL) wearing time.
Methods: A systematic review with meta-analysis, reporting on the efficacy and/or safety of eyelid warming therapies for CLDE and/or comfortable CL wearing time in three databases, PubMed, Scopus and Web of Science, was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement.
Results: Four randomised controlled trials were included. Analyses revealed significant differences only between eyelid warming therapies and negative controls for ocular surface disease index scores (mean difference (MD): 19.57; 95% CI: 12.51-26.64; I2 = 0%; p 2 = 0%; p = 0.15), lipid layer thickness (MD: 4.54; 95% CI: -5.73 to 14.81; I2 = 0%; p = 0.39) or comfortable CL wearing time (MD: -0.06; 95% CI: -1.19 to 1.06; I2 = 0%; p = 0.91) when compared with positive controls, nor in the Schirmer test when compared with negative/positive controls (MD: -0.46; 95% CI: -4.17 to 3.25; I2 = 24%; p = 0.81). Regarding safety, most studies reported no adverse events and demonstrated a satisfactory tolerability profile for eyelid warming therapies. However, a meta-analysis could not be performed.
Conclusions: The efficacy of eyelid warming therapies for alleviating CLDE and improving comfortable CL wearing time is limited. Further randomised controlled trials following…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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