Gut microbiome modulation can improve cognitive function in older adults: a systematic review and meta-analysis
Abstract
Background: Age-related cognitive decline and dementia exert increasing pressure on healthcare systems. Gut microbiome modulation may offer a novel approach to improving cognitive health.
Objective: To establish the effect of gut microbiome modulation on cognitive function in older adults.
Methods: A systematic search was conducted of PubMed, Cochrane Library, Medline and Embase (OVID) to identify randomised controlled trials (RCTs) and observational studies assessing cognitive outcomes in adults aged ≥60. Interventions aimed at modifying the gut microbiome (prebiotics, probiotics, synbiotics) were included. Studies involving faecal transplants or comparing modifiers to one another instead of to placebo were excluded. Changes in cognitive function were measured by neuropsychological assessments and standardised cognitive tests (e.g. MMSE, MoCA).
Results: Fourteen studies met inclusion criteria (13 RCTs, 1 interventional study), consisting of 10 probiotic, 2 prebiotic and 2 synbiotic trials. Participants included both healthy older adults and those with cognitive impairment. Nine studies reported statistically significant improvements in at least one cognitive domain, particularly global cognition, memory, attention and executive function. Meta-analysis of a sub-group resulted in a statistically significant (MD = 1.28; 95% CI = 0.15-2.40; P < 0.05) improvement in global cognition scores after supplementation.
Conclusions: Gut microbiome modulation through probiotic, prebiotic…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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