The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies
Abstract
Background: Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and the second leading cause of cancer-related mortality. Based on recent studies, lipid levels may have a relationship with the risk of CRC. This meta-analysis aims to better understand the association between various serum lipids and CRC risk.
Methods: A comprehensive search was conducted in Web of Science, PubMed, and Scopus. This meta-analysis, including only prospective cohort studies, performed random-effects meta-analyses using the Restricted Maximum Likelihood (REML) model to assess the association between the highest versus lowest categories of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoproteins (LDL) with the risk of CRC, primarily using hazard ratios (HR) as the effect size. Subgroup analyses (e.g., by tumor site, region, and risk of bias) and meta-regression analyses (e.g., for mean age, mean BMI, sex distribution, and duration of follow-up) were conducted to explore heterogeneity. Dose-response analyses were performed utilizing three model types.
Results: Following the screening of 27,278 articles, 23 articles have been included in this study finally. The associations between TG, TC, HDL, and LDL levels and the risk of CRC, colon, and rectum cancers were examined separately. Higher levels of TC were not significantly associated with the risk of CRC (HR = 1.08; 95% CI: 0.90-1.30; I2 = 50.55%; p = 0.4187) and colon cancer…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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