Global research landscape and hotspots of paraptosis: a multi-database bibliometric analysis with a focused literature review
Abstract
Background: Paraptosis is a non-canonical form of programmed cell death distinct from apoptosis and morphologically characterized by prominent cytoplasmic vacuolation. However, a systematic assessment of the overall development, research landscape, and hotspot evolution of paraptosis remains lacking. This study therefore used bibliometric methods to systematically map paraptosis-related publications, and provide an evidence-based reference for future research.
Methods: Using "paraptosis" as the core search term, we systematically retrieved paraptosis-related publications from the Web of Science Core Collection, PubMed, and Scopus from database inception to December 31, 2025. Only English-language articles and reviews were included. VOSviewer, CiteSpace, R, and Excel were used to analyze and visualize publication trends, collaboration networks, journal distribution, co-citation relationships, keyword co-occurrence, clustering, and thematic evolution.
Results: A total of 401 publications were included. Annual output showed an overall fluctuating upward trend, with marked growth from 2020 to 2025. China (n = 155) and Ajou University (n = 19) were the most productive country and institution, respectively, and Choi Kyeong Sook was a representative core author. Journals in this field mainly focused on cell death and related mechanisms, cancer and molecular mechanisms, and chemical biology and drug research, whereas the knowledge base was primarily grounded in basic life sciences.…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 356 participants or records.
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