MRI and PET-Based Machine Learning Radiomics for Metastasis Prediction in Pancreatic Ductal Adenocarcinoma: A Systematic Review
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor survival, driven in part by early metastatic spread. Conventional imaging lacks sufficient precision to predict metastasis accurately. Machine learning (ML)-based radiomics, integrating quantitative imaging features from modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET), may enhance prognostic accuracy.
Objective: To systematically review the diagnostic accuracy and clinical utility of ML-based radiomics models for predicting metastasis in PDAC.
Methods: A systematic search of PubMed, Embase, Scopus, Web of Science, and Cochrane Library was conducted according to PRISMA 2020 guidelines (PROSPERO: CRD420251109941). Eligible studies applied ML-based radiomics to MRI, PET, or combined MRI/PET for metastasis prediction in histologically or clinically confirmed PDAC. Data were extracted on study design, patient characteristics, imaging protocols, feature selection, ML algorithms, performance metrics, and validation strategies. Methodological quality was assessed using QUADAS-2. Certainty of evidence was graded using the GRADE framework.
Results: Seven studies met inclusion criteria and were included in the Systematic Review. MRI-based models were the most common, with one multimodal PET/MRI study. Risk of bias was moderate overall, primarily due to retrospective designs and variable reference standards. GRADE certainty was low for pooled diagnostic…
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Evidence Hub reads this as a systematic review, done in computer models (in silico), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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