A bibliometric and text-mining analysis of lipidomics and metabolomics in human disease
Abstract
Introduction: Lipidomics and metabolomics have become key approaches for understanding and diagnosing human diseases, including type 2 diabetes, Alzheimer's disease, cancer, and kidney dysfunction. This study provides a comprehensive overview of the evolution of these disciplines through a bibliometric and text-mining analysis of scientific production from 2004 to 2024, based on data from Scopus and validated through a multi-database comparative approach.
Methods: A total of 9,628 articles were harmonized and analyzed using Bibliometrix, Scimago Graphica, OpenRefine, and custom R scripts to identify the most productive journals, authors, countries, and institutions, and to map thematic structures and keyword dynamics. Beyond traditional bibliometric indicators, our integrative approach combined quantitative trends with semantic and conceptual mapping to trace the methodological and translational evolution of the field. To ensure robustness and generalizability, equivalent searches were conducted in the Web of Science Core Collection and PubMed, and cross-database validation assessed concordance in journal and country rankings, as well as temporal and thematic trends.
Results: The field shows rapid expansion, with an annual growth rate of 32.6%. The United States and China lead global output, followed by major European contributors. Core topics include Alzheimer's disease, obesity, and breast cancer, while emerging areas focus on artificial intelligence, multi-omics…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Preliminary Toxicity Analysis of 3DCRT versus IMRT on the High Dose Arm of the RTOG 0126 Prostate Cancer Trial
- Adaptive Radiotherapy for Head and Neck Cancer: Initial Clinical Outcomes from a Prospective Trial
- American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology
- Motion Management Strategies and Technical Issues Associated with Stereotactic Body Radiotherapy of Thoracic and Upper Abdominal Tumors: A Review from NRG Oncology
- High-dose-rate interstitial brachytherapy as a monotherapy for localized prostate cancer: treatment description and preliminary results of a phase I/II clinical trial
- Highly efficient training, refinement, and validation of a knowledge-based plan quality control system for radiotherapy clinical trials
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.