The research perspectives and frontiers on radiotherapy for hepatocellular carcinoma: a bibliometric analysis and systematic review
Abstract
Introduction: Research into radiotherapy(RT) for hepatocellular carcinoma(HCC) has significantly advanced, underscoring its critical role in systemic therapy. However, there remains a notable lack of quantitative and analytical studies specifically addressing RT in the context of HCC. This study aims to evaluate the evolution of RT research and provide a comprehensive analysis of RT studies using bibliometric citation analysis.
Methods: A literature search was conducted on July 2, 2024, to extract relevant publications from the Science Citation Index-Expanded(SCIE) of the Web of Science Core Collection(WoSCC), spanning the years 2014 to 2023. Bibliometric and quantitative assessments of the collected publications were performed using visualization tools such as CiteSpace and VOSviewer.
Results: The research identified 822 manuscripts authored by 4681 researchers from 1083 institutions across 17 countries, published in 225 journals, and involving 16183 co-cited references from 2282 journals. The United States led in publication volume with 147 articles (17.9%), showing close collaboration with Canada and China. Key areas of focus included the use of RT for HCC with portal vein tumor thrombosis and its combination with transarterial chemoembolization for advanced HCC treatment, which have garnered significant global interest. Recently, particle therapy and the integration of targeted therapies and immunotherapy with RT have emerged as critical themes and frontiers in this…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Preliminary Toxicity Analysis of 3DCRT versus IMRT on the High Dose Arm of the RTOG 0126 Prostate Cancer Trial
- Adaptive Radiotherapy for Head and Neck Cancer: Initial Clinical Outcomes from a Prospective Trial
- American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology
- Motion Management Strategies and Technical Issues Associated with Stereotactic Body Radiotherapy of Thoracic and Upper Abdominal Tumors: A Review from NRG Oncology
- High-dose-rate interstitial brachytherapy as a monotherapy for localized prostate cancer: treatment description and preliminary results of a phase I/II clinical trial
- Highly efficient training, refinement, and validation of a knowledge-based plan quality control system for radiotherapy clinical trials
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.