Evidence Hub

The Mediating Effects of Digital Music Therapy on Depressive Symptoms in Youth During the COVID-19 Pandemic: A Randomized Controlled Trial

Zhu Y, Tang R, Zhang H, Wang Y, Yu Y, Qin S, Zhang Q, Tu J et al.

Stress and health : journal of the International Society for the Investigation of Stress, 2026

105 participants

Abstract

The COVID-19 pandemic has become a major psychosocial stressor, exacerbating depressive symptoms among youth. Amid escalating environmental stressors, early intervention is essential. Digital music therapy (dMT) shows promise; however, stress-context randomized controlled trials examining its effectiveness and mechanisms are lacking. A total of 1581 youths were identified with depressive symptoms via survey. In a randomized trial, 105 participants were 1:1 assigned to the dMT or control (CON) group. The dMT group received 3 weeks of intervention, while the CON group received none. The primary outcome will assess depression changes ( Δ${\Delta }$ ) of pre- and post-intervention, compared to CON group. Secondary outcomes will evaluate Δ${\Delta }$ Stress and Δ${\Delta }$ Insomnia, compared to CON group. Mediation analysis examined depressive symptoms' role in mediating stress and insomnia, further assessed dMT efficacy's mediating role in these outcomes. There were significant differences in Δ${\Delta }$ Depression, Δ${\Delta }$ Stress, and Δ${\Delta }$ Insomnia between dMT group (n = 30) and CON group (n = 30). Depressive symptoms directly and indirectly mediated the relationship between stress and insomnia among depressive youth identified via survey. The therapeutic effect of the dMT intervention on Δ${\Delta }$ Depression indirectly mediated the relationship between Δ${\Delta }$ Stress and Δ${\Delta }$ Insomnia. Digital MT-driven depression improvement mediates stress and…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 105 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free