HyperSight CBCT dose calculation accuracy for adaptive head and neck radiotherapy: Results from a prospective clinical trial
Abstract
Background: Head and neck (H&N) patients frequently undergo anatomical changes such as weight loss and tumour shrinkage during treatment, requiring repeat imaging and replanning to maintain accurate dose delivery. On-board cone-beam CT (CBCT) systems could support these workflows, however they have historically been limited by reduced Hounsfield unit accuracy, inferior image quality, and susceptibility to metal artifacts from dental hardware, all of which are critical for effective radiotherapy treatment planning and dose delivery. HyperSight CBCT offers improved image quality comparable to FBCT along with metal artifact reduction techniques, but its dosimetric performance in H&N patients, particularly in the presence of dental metal implants, has not yet been evaluated.
Purpose: This work evaluates the dosimetric accuracy of the HyperSight CBCT system (Varian Medical Systems), including the impact of metal artifact reduction, to determine its reliability for H&N treatment planning.
Methods: Images of 25 H&N cancer patients were acquired on a conventional fan-beam CT (FBCT. GE Healthcare) and on two CBCT systems: an Ethos radiotherapy system equipped with HyperSight CBCT, which provides advanced iterative reconstruction (HS-Acuros) and metal artifact reduction reconstruction (HS-MAR) options, and a TrueBeam linear accelerator system with conventional CBCT, which uses filtered back projection reconstruction (Varian Medical Systems). For each patient, the CBCTs were rigidly…
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Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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