Results from iroc houston’s anthropomorphic proton phantoms used for clinical trial credentialing
Abstract
Purpose To summarize the findings of anthropomorphic proton phantom irradiations analyzed by the Imaging and Radiation Oncology Core (IROC) Houston. Methods and Materials 103 phantoms were irradiated by proton therapy centers participating in clinical trials. The anthropomorphic phantoms simulated heterogeneous anatomy of a head, liver, lung, prostate, and spine. Treatment plans included those for scattered, uniform scanning, and pencil beam scanning beam delivery modalities using five different treatment planning systems. For every phantom irradiation, point doses and planar doses were measured using TLD and film, respectively. The difference between measured and planned dose was studied as a function of phantom, beam delivery modality, motion, repeat attempt, treatment planning system, and date of irradiation. Results The phantom pass rate (overall 79%) is high for simple phantoms and lower for phantoms that introduce higher levels of difficulty, such as motion, multiple targets, or increased heterogeneity. All treatment planning systems overestimated dose to the target, as compared to TLD measurements. Errors in range calculation resulted in several failed phantoms. There was no correlation between TPS and pass rate. The pass rates for each individual phantom are not improving over time, but when individual institutions received feedback about failed phantom irradiations, pass rates did improve. Conclusions The proton phantom pass rates are not as high as desired and…
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