Development of a self-reporting electrochemical sensor utilizing CoNiFe-PBA for detection of BPA in food Samples
Abstract
Abstract Bisphenol A (BPA), a widely used endocrine-disrupting chemical, poses significant health risks due to its potential to migrate from food packaging into food products. In this study, we developed a self-reporting electrochemical sensor based on molecular imprinting technology for the detection of BPA in food samples. The sensor was constructed through sequential modification of the electrode with reduced graphene oxide (RGO) and CoNiFe Prussian blue analogue (CoNiFe-PBA). The resulting configuration exhibited a self-reporting signal at ~ 0.47 V (vs. Ag/AgCl), arising from the synergistic redox interplay of the multi-metal centers in CoNiFe-PBA. The MIP film was synthesized via electropolymerization, employing BPA as the template and o-phenylenediamine ( o -PD) as the functional monomer. Under optimal conditions, the sensor demonstrated a wide linear detection range (0.5–500 nM) and a low detection limit (0.19 nM). Owing to its high selectivity, sensitivity, and accuracy, the sensor offers a reliable approach for precise quantification of trace BPA in complex food matrices.
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