Flexible electrochemical sensor with Fe/Co bimetallic oxides for sensitive analysis of glucose in human tears
Abstract
The construction of uniformly dispersed structure with abundant active sites is crucial for fast electron transport and advancing electrocatalytic reactions. Herein, FexCoyO4-rGO was prepared by depositing Fe and Co bimetallic oxides in-situ on reduced graphene oxide through a simple process combined hydrothermal reaction and calcination. Fe was elaborately introduced into the synthesis of metal oxides to alleviate the aggregation of cobalt oxides and obtain nanocomposites with homogeneously structured and abundant redox sites, and the bimetallic oxides nanomaterials had enhanced electrocatalysis under the synergistic effect. The flexible electrode prepared from FexCoyO4-rGO exhibited excellent detection performance for glucose with a detection limit down low to 0.07 μM and a sensitivity of 1510 μM cm-2 mA-1. The adoption of flexible substrates improved the wearability of the electrode and broadened its practicality for detecting biomarkers on the skin surface. The constructed sensor was successfully used in the dynamic analysis of glucose content in tears, and the results were highly consistent with the test outcome of a commercial test kit, demonstrating its application prospects in non-invasive epidermal diabetes mellitus diagnosis.
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